In China, there are about 20-30 million birth defects per year. The total number of children with congenital disabilities is up to 60-120 million, accounting for about 4%-6% of the total number of births per year.The total incidence of neural tube malformation in China is high. How to effectively reduce the incidence of neural tube malformation is a hot spot of current research.

Product introduction

    Folic acid (Folate) is a water-soluble B vitamins and a necessary vitamin for the synthesis of DNA. Folic acid is an indispensable substance for the manufacture of red blood cells,  associated with vitamin B12 promoting the formation and maturation of red blood cells,  and participates in the whole process of metabolism of the human body. The fluorescence PCR melting curve technique was used to detect the C677T and A1298C site of the MTHFR gene and the A66G site of the MTRR gene in the gene detection of folic acid metabolism.The genotypes were used to evaluate the ability of the individuals to utilizing the folic acid. Gene detection by folate metabolism can predict the absorption and utilization ability of folic acid among individuals, and help achieve guidances of personalized folic acid supplementation, which is of great significance for clinical medication.

Female folic acid deficiency and excessive harm

Related genes of folic acid

Detection significance

1. early prediction of the uptake and utilization of folic acid by different individuals, so as to screen out high risk people who are prone to folate deficiency.

2. the realization of individualized supplementation of folic acid, strengthening the compliance of folic acid, is of great significance to the guidance of clinical medication.

3. to strengthen prenatal screening and prenatal diagnosis for neural tube defects and to reduce the risk of birth defects.

Detection advantage

Detection process

Intended for

1. Early prediction of the ability of folic acid uptake and utilization for different individuals, so as to screen out high risk people who are prone to folate deficiency.

2. The realization of individualized supplementation of folic acid, strengthening the compliance of folic acid, is of great significance to the guidance of clinical medication.

3. To strengthen prenatal screening  for neural tube defects and to reduce the risk of birth defects.